Obesity Hypoventilation (OHS)
Virtually every kind of sleep disordered breathing has been described in persons with PWS (Vela Bueno 1984; Hertz, 1993; Hertz; 1995; Schluter, 1997; Klift, 1994; Richards, 1993; Vgontzas, 1995) including the non obese child or adult. Hypoventilation is characterized by “constant or slowly diminishing oxyhemoglobin desaturation without the cyclic, episodic or repetitive changes in oxygen saturation associated with apneas and hypopneas or the arousal that terminates these abnormal breathing events.” This sustained hypoxia is the typical pattern seen on sleep pulse oximetry of obese patients with PWS and is relatively uncommon in non- PWS obese persons (Von Boxem 1999; Koenig 2001). OHS persons ultimately develop reduced lung volume (Bedell, 1958; Holley 1967).
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